The Vena8 Endothelial+™ biochip is ideal for studying cell-cell interaction. Endothelial cells are easily seeded (via standard pipette) and cultured inside the microcapillaries of the biochip. As cells flow through the microcapillary of the Vena8 Endothelial+™ biochip, the cell surface receptors may interact with the endothelial cell monolayer which coats the microcapillary walls. Ideal for use with phase contrast imaging and fluorescence imaging to study cell-cell interactions under conditions mimicking physiological flow.
Vena8 Endothelial+TM biochip
Illustration close-up:
Cell adhesion inside cell-cultured microchannel of Vena8 Endothelial+™ biochip
Example: Adhesion of THP-1 monocytes at shear stress of 0.5 dyne/cm2 to primary HUVEC cultured in microcapillary
Inflammation - Atherosclerosis: THP-1 monocytes adhering to HUVECs in biochip under flow
Atherosclerosis: primary monocyte adhesion to coronary artery endothelium under shear flow
Inflammation: PMA stimulated T-cells adhering to non-stimulated HUVECs under shear flow
Primary Endothelial Cell Culture in Cellix's Vena8 Endothelial+TM biochips. Cells seeded at high density and place in a standard incubator. Monolayer achieved in less than 3 hours!
Each biochip contains 8 capillaries in parallel which can be seeded with endothelial cells for culture of 8 monolayers in parallel and subsequent study of cell-cell interaction studies under shear flow. Each 10 pack contains 80 assays. Each 5 pack contains 40 assays.
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